Journal article
Annie Jeffery, J. Buckman, Emma Francis, Kate Walters, Ian C. K. Wong, Ian C K. Wong cd, David Osborn, Joseph F. Hayes
medRxiv, 2022
medRxiv, 2022
Semantic Scholar
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APA
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Jeffery, A., Buckman, J., Francis, E., Walters, K., Wong, I. C. K., cd, I. C. K. W., … Hayes, J. F. (2022). A Systematic Review of Long-term Antidepressant Outcomes in Comorbid Depression and Type 2 Diabetes. MedRxiv.
Chicago/Turabian
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Jeffery, Annie, J. Buckman, Emma Francis, Kate Walters, Ian C. K. Wong, Ian C K. Wong cd, David Osborn, and Joseph F. Hayes. “A Systematic Review of Long-Term Antidepressant Outcomes in Comorbid Depression and Type 2 Diabetes.” medRxiv (2022).
MLA
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Jeffery, Annie, et al. “A Systematic Review of Long-Term Antidepressant Outcomes in Comorbid Depression and Type 2 Diabetes.” MedRxiv, 2022.
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@article{annie2022a,
title = {A Systematic Review of Long-term Antidepressant Outcomes in Comorbid Depression and Type 2 Diabetes},
year = {2022},
journal = {medRxiv},
author = {Jeffery, Annie and Buckman, J. and Francis, Emma and Walters, Kate and Wong, Ian C. K. and cd, Ian C K. Wong and Osborn, David and Hayes, Joseph F.}
}
Abstract
Background: Depression is a common and chronic comorbidity affecting approximately one in four people with type 2 diabetes (T2DM), and often lasting several years. Past systematic reviews have been unable to identify evidence for longterm (12+ months) antidepressant treatment outcomes in comorbid depression and type 2 diabetes. These reviews are >10years old, included only randomised controlled trials or had limited search strategies. We aimed to systematically review observational studies for long-term outcomes of antidepressant treatment in adults with comorbid depression and T2DM, including broader, up-to-date searches. Methods and findings: This review was pre-registered on PROSPERO (CRD42020182788). We searched seven databases using terms related to depression, T2DM and antidepressant medication. From 14,389 reports retrieved, 63 were screened at full text stage and 0 met inclusion criteria. The reasons for exclusion at full text stage were: Studies did not meet inclusion criteria for antidepressant treatment (n = 50); studies did not meet inclusion criteria for T2DM (n = 36); studies did not meet inclusion criteria for depression (n = 29); studies did not include follow-up time (n = 25); studies did not meet inclusion criteria for observational study (n = 14); studies did not include any measurable outcomes (n = 5); studies did not include a suitable comparison (n = 3). Conclusions: We found no evidence concerning long-term outcomes of antidepressant treatment in individuals with comorbid depression and T2DM. Insufficient ascertainment of antidepressant prescription, case identification, and short follow-up times are the primary reasons for this. Research is urgently required to determine long-term outcomes associated with antidepressant treatment in this patient group