Journal article
Annie Jeffery, C. Bhanu, K. Walters, I. Wong, D. Osborn, Joseph F Hayes
British Journal of General Practice, 2022
British Journal of General Practice, 2022
Semantic Scholar
DOI
Cite
Cite
APA
Click to copy
Jeffery, A., Bhanu, C., Walters, K., Wong, I., Osborn, D., & Hayes, J. F. (2022). Polypharmacy and Antidepressant Acceptability in Comorbid Depression and Type 2 Diabetes. British Journal of General Practice.
Chicago/Turabian
Click to copy
Jeffery, Annie, C. Bhanu, K. Walters, I. Wong, D. Osborn, and Joseph F Hayes. “Polypharmacy and Antidepressant Acceptability in Comorbid Depression and Type 2 Diabetes.” British Journal of General Practice (2022).
MLA
Click to copy
Jeffery, Annie, et al. “Polypharmacy and Antidepressant Acceptability in Comorbid Depression and Type 2 Diabetes.” British Journal of General Practice, 2022.
BibTeX Click to copy
@article{annie2022a,
title = {Polypharmacy and Antidepressant Acceptability in Comorbid Depression and Type 2 Diabetes},
year = {2022},
journal = {British Journal of General Practice},
author = {Jeffery, Annie and Bhanu, C. and Walters, K. and Wong, I. and Osborn, D. and Hayes, Joseph F}
}
Abstract
BACKGROUND: Polypharmacy may increase the risk of drug interactions, side-effects and poor adherence. However, the impact of polypharmacy on antidepressant acceptability in individuals with type 2 diabetes (T2DM) is unknown. AIM: In adults with T2DM, to investigate the association between the number of prescribed medications and: i) early antidepressant discontinuation (<32 weeks); ii) switching antidepressant agents. DESIGN: Cohort study using UK primary care data from the years 2000-2018. METHODS: We used cox regression with penalised B-splines to describe the association between the number of concurrently prescribed medications at the time of starting antidepressant treatment, and each of our outcomes. RESULTS: We identified 73,808 individuals with comorbid depression and T2DM starting antidepressant treatment for the first time. The median number of concurrent medications prescribed was 7. Within 32 weeks, 44.26% of participants discontinued antidepressant treatment altogether, and 11.75% of participants switched antidepressant agents. We found an inverse relationship between the number of concurrent medications and discontinuing antidepressant treatment altogether. The median number of 7 concurrent medications was associated with a 65.06% decrease early antidepressant discontinuation HR 0.45, 95% CIs 0.37-0.55). We found no evidence of an association, in our main analysis, between the number of concurrent medications and switching antidepressant agents. CONCLUSIONS: Early discontinuation of antidepressants is common in adults with T2DM. However, individuals with higher levels of concurrent polypharmacy may be more adherent to treatment. These are likely to represent individuals with worse physical/mental health. Individuals with lower levels of concurrent polypharmacy may benefit from adherence support.
