Journal article
J. Hayes, D. Osborn, A. Lundin, C. Dalman
Journal of psychopharmacology, 2019
Journal of psychopharmacology, 2019
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DOI
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APA
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Hayes, J., Osborn, D., Lundin, A., & Dalman, C. (2019). Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis. Journal of Psychopharmacology.
Chicago/Turabian
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Hayes, J., D. Osborn, A. Lundin, and C. Dalman. “Psychiatric Hospitalization Following Antipsychotic Medication Cessation in First Episode Psychosis.” Journal of psychopharmacology (2019).
MLA
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Hayes, J., et al. “Psychiatric Hospitalization Following Antipsychotic Medication Cessation in First Episode Psychosis.” Journal of Psychopharmacology, 2019.
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@article{j2019a,
title = {Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis},
year = {2019},
journal = {Journal of psychopharmacology},
author = {Hayes, J. and Osborn, D. and Lundin, A. and Dalman, C.}
}
Abstract
Background: There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation. Aim: The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure. Methods: We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007–31 December 2016 (n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years). Results: Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1–4 years after treatment cessation. Conclusion: We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.