Personalised medicine aims to assign a patient the optimal treatment, based on their predicted response; thereby moving from average group outcomes towards the prediction of outcomes for individual patients. The challenge of choosing a drug treatment for a particular patient with mental illness could be guided by an understanding of patient characteristics associated with better treatment outcomes. In the case of personalising treatment for severe mental illness, there is ongoing work focusing on genome-wide associations and biomarkers (for example, from functional magnetic resonance imaging and electroencephalography). However, these approaches have yet to bear fruit clinically; early attempts have been plagued by failures to replicate findings and small sample sizes. In the case of genomics, the low frequency of identified response-associated alleles means genetic testing alone is yet to be predictive in patients. Many of these approaches will also be challenging to deliver in routine practice, but any valid prediction arising from this work could be paired with the methods the aiMH lab is implementing.
Personalised medicine aims to assign a patient the optimal treatment, based on their predicted response; thereby moving from average group outcomes towards the prediction of outcomes for individual patients. The challenge of choosing a drug treatment for a particular patient with mental illness could be guided by an understanding of patient characteristics associated with better treatment outcomes. In the case of personalising treatment for severe mental illness, there is ongoing work focusing on genome-wide associations and biomarkers (for example, from functional magnetic resonance imaging and electroencephalography). However, these approaches have yet to bear fruit clinically; early attempts have been plagued by failures to replicate findings and small sample sizes. In the case of genomics, the low frequency of identified response-associated alleles means genetic testing alone is yet to be predictive in patients. Many of these approaches will also be challenging to deliver in routine practice, but any valid prediction arising from this work could be paired with the methods the aiMH lab is implementing.
Publications
A. Richards-Belle, N. Launders, S. Hardoon, Alexander L. Richards, K. K. Man, N. Davies, E. Bramon, Joseph F Hayes, David P J Osborn
PLoS Medicine, 2025
Michail Kalfas, Dimosthenis Tsapekos, Matthew Butler, Robert A. McCutcheon, T. Pillinger, R. Strawbridge, Bhagyashree Bhaskar Bhat, Peter M. Haddad, Phil Cowen, Oliver D. Howes, Dan W Joyce, D. J. Nutt, David S. Baldwin, Carmine M. Pariante, Gemma Lewis, Allan H. Young, Glyn Lewis, Joseph F Hayes, S. Jauhar
JAMA psychiatry, 2025
N. Launders, C. Jackson, Joseph F Hayes, A. John, Robert Stewart, M. Iveson, E. Bramon, Bruce Guthrie, Stewart W. Mercer, D. Osborn
The British journal of psychiatry : the journal of mental science, 2025
Sean Halstead, Chloe X Yap, N. Warren, Sri Mahavir Agarwal, B. Brand, Sherry Kit Wa Chan, A. Cipriani, C. Correll, N. Crossley, Enrico D'Ambrosio, R. Emsley, Joseph Firth, Fiona Gaughran, S. Gee, Margaret Hahn, Joseph F Hayes, A. Heald, Oliver D Howes, John M. Kane, Maria Kapi, Stefan Leucht, Nicholas Meyer, Brian O’Donoghue, Emmanuel Okeke, Benjamin I Perry, Marco Solmi, Iris E. Sommer, Vivek Srivastava, H. Taipale, David Taylor, J. Tiihonen, Allan H Young, Robert A. McCutcheon, D. Siskind, T. Pillinger
Lancet psychiatry, 2025
Danielle Nimmons, J. C. Bazo-Alvarez, C. Avgerinou, Joseph Hayes, David Osborn, Claudia Cooper, I. Petersen, Kate Walters
BJPsych Open, 2024
Danielle Nimmons, J. C. Bazo-Alvarez, C. Avgerinou, Joseph Hayes, David P J Osborn, Claudia Cooper, I. Petersen, Kate Walters
BJPsych Open, 2024
Joseph F Hayes, Fehmi Ben Abdesslem, Sandra Eloranta, David P J Osborn, M. Boman
PeerJ, 2024
N. Launders, C. Jackson, Joseph F Hayes, A. John, Robert Stewart, M. Iveson, E. Bramon, Bruce Guthrie, Stewart W. Mercer, David Osborn
medRxiv, 2024
Systemic medications and dementia risk: an umbrella review
N. Mukadam, Clara Belessiotis, Ying Feng Yap, Shivangi Talwar, Andrea Bruun, Wenqianglong Li, Harry Ward, Pilar A Letrondo, Madeleine Morelli‐Batters, Rongyu Lin, Michelle Eskinazi, Talen Wright, Joseph Hayes
Alzheimer's & Dementia, 2024
Lithium and the risk of fractures in patients with bipolar disorder: A population-based cohort study
V. W. Ng, M. T. Leung, W. Lau, Esther W. Chan, Joseph F. Hayes, David P J Osborn, Ching-Lung Cheung, Ian C. K. Wong, K. Man
Psychiatry Research, 2024
Yehudit Bauernfreund, N. Launders, Graziella Favarato, Joseph F Hayes, D. Osborn, Elizabeth L. Sampson
Psychological Medicine, 2024
Alasdair D. Henderson, Elizabeth I Adesanya, A. Mulick, J. Matthewman, Nhung Vu, Firoza Davies, Catherine Smith, Joseph F Hayes, K. Mansfield, S. Langan
BMC Medicine, 2023
Caige Huang, Yue Wei, Vincent K. C. Yan, Xuxiao Ye, Wei Kang, H. H. Yiu, J. Shami, B. Cowling, M. Tse, D. J. Castle, C. Chui, F. Lai, Xia Li, E. Wan, C. Wong, Joseph F Hayes, W. Chang, A. K. Chung, Chak S. Lau, I. Wong, E. Chan
Lancet psychiatry, 2023
Elizabeth I Adesanya, Alasdair D Henderson, J. Matthewman, K. Bhate, Joseph F Hayes, A. Mulick, R. Mathur, Catherine Smith, H. Carreira, S. Rathod, S. Langan, K. Mansfield
Clinical Epidemiology, 2023
Predicting Lithium vs Olanzapine Treatment Response in Bipolar Disorder Using Machine Learning
Joseph F. Hayes, Fehmi Ben Abdesslem, M. Boman, David Osborn
Social Science Research Network, 2023
Justin C Yang, Johan H Thygesen, N. Werbeloff, David Kelsey, Dominique Merlande, Joseph Hayes, David PJ Osborn
medRxiv, 2023
Electronic screening for mental illness in patients with psoriasis
K. Bechman, Joseph F Hayes, Julian Mathewman, Alasdair D. Henderson, Elizabeth I Adesanya, K. Mansfield, Catherine H. Smith, J. Galloway, S. Langan
British Journal of Dermatology, 2023
J. Hayes, S. Hardoon, J. Deighton, E. Viding, D. Osborn
Journal of Psychopharmacology, 2022
V. W. W. Ng, Le Gao, E. Chan, Ho Ming Edwin Lee, J. Hayes, D. Osborn, T. Rainer, K. Man, I. C. Wong
Psychological medicine, 2022
Yue Wei, Vincent K. C. Yan, Wei Kang, I. Wong, D. J. Castle, Le Gao, C. Chui, K. Man, J. Hayes, W. Chang, E. Chan
JAMA network open, 2022
J. Hayes, D. Osborn, E. Francis, G. Ambler, L. Tomlinson, M. Boman, I. Wong, J. Geddes, C. Dalman, Glyn Lewis
BMC Medicine, 2021